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Review
. 2017 Feb 20:12:1401-1413.
doi: 10.2147/IJN.S124855. eCollection 2017.

Cerium oxide nanoparticles: green synthesis and biological applications

Fahimeh Charbgoo  1 , Mansor Bin Ahmad  2 , Majid Darroudi  3
Affiliations
Review

Cerium oxide nanoparticles: green synthesis and biological applications

Fahimeh Charbgoo et al. Int J Nanomedicine. .

Abstract

CeO2 nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO2-NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO2-NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO2-NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine. This review discusses the different green strategies for CeO2-NPs synthesis, their advantages and challenges that are to be overcome. In addition, this review focuses on recent progress in the potential application of CeO2-NPs in biological and medical fields. Exploiting biocompatible CeO2-NPs may improve outcomes profoundly with the promise of effective neurodegenerative therapy and multiple applications in nanobiotechnology.

Keywords: biocompatibility; cerium oxide nanoparticles; green synthesis; morphology; size; surface Ce3+.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Schematic representation of Gloriosa superba-based method of cerium oxide nanoparticle synthesis.
Figure 2
Figure 2
Schematic representation of the Gum base method of CeO2-NP synthesis. Abbreviation: CeO2-NPs, cerium oxide nanoparticles.
Figure 3
Figure 3
Major parameters affect the cytotoxicity of CeO2-NPs. Abbreviation: CeO2-NPs, cerium oxide nanoparticles.
Figure 4
Figure 4
Superoxide dismutase mimetic activity of CeO2-nanoparticles.
Figure 5
Figure 5
H2O2 could make displacement of adsorbed DNA from CeO2-NPs, resulting in fluorescence signal enhancement. Abbreviation: CeO2-NPs, cerium oxide nanoparticles.
See this image and copyright information in PMC

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