Association of carotid atherosclerosis and recurrent cerebral infarction in the Chinese population: a meta-analysis

Abstract

Stroke, when poor blood flow to the brain results in cell death, is the third leading cause of disability and mortality worldwide, and appears as an unequal distribution in the global population. The cumulative risk of recurrence varies greatly up to 10 years after the first stroke. Carotid atherosclerosis is a major risk factor for stroke. The aim of this study was to investigate and estimate the relationship between carotid atherosclerosis and risk of stroke recurrence in the Chinese population. We performed a systematic review and meta-analysis of randomized controlled trials published from 2000 to 2013, using the following databases: PubMed, Embase, Medline, Wanfang, and the China National Knowledge Infrastructure. The odds ratios with 95% confidence intervals were calculated to examine this strength. A total of 22 studies, including 3,912 patients, 2,506 first-ever cases, and 1,406 recurrent cases, were pooled in this meta-analysis. Our results showed that the frequency of carotid atherosclerosis is higher in recurrent cases than that in the first-ever controls (78.88% vs 59.38%), and the statistical analysis demonstrated significant positive association between carotid atherosclerosis and recurrent cerebral infarction (odds ratio: 2.87; 95% confidence interval: 2.42-3.37; P<0.00001) in a fixed-effect model. No significant heterogeneity was observed across all studies. In conclusion, our results showed that carotid atherosclerosis was associated with increased risk of recurrent stroke. However, further well-designed research with large sample sizes is still needed to identify the clear mechanism.

Keywords: carotid atherosclerosis; cerebral infarction; meta-analysis.

Figure 1

Flowchart of literature screening.

Figure 2

Forest plot of the association between carotid atherosclerosis and recurrent carotid atherosclerosis in the Chinese population. Abbreviations: M–H, Mantel–Haenszel; CI, confidence interval; df, degrees of freedom.

Figure 3

Funnel plot of the association between carotid atherosclerosis and recurrent carotid atherosclerosis. Abbreviations: SE, standard error; OR, odds ratio.