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Review
. 2017 Feb 14:11:63.
doi: 10.3389/fnins.2017.00063. eCollection 2017.

The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise

Shinya Aoyama  1 , Shigenobu Shibata  2
Affiliations
Review

The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise

Shinya Aoyama et al. Front Neurosci. .

Abstract

The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone. Peripheral clocks are controlled by not only photic stimulation from the central clock in the SCN but also by external cues, such as feeding and exercise. In this review, we discuss the effects of feeding and exercise on the circadian clock and diurnal variation of musculoskeletal functions. We also discuss the therapeutic potential of chrono-nutrition and chrono-exercise on circadian disturbances and the failure of homeostasis in skeletal muscle and bone.

Keywords: bone; chrono-exercise; chrono-nutrition; circadian rhythm; clock gene; skeletal muscle.

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Figures

Figure 1
Figure 1
The diurnal regulation of skeletal muscle and osseous functions by circadian clock systems and chrono-exercise and –nutrition. The master clock in the suprachiasmatic nucleus (SCN) is reset by a photic cue and it regulates the peripheral circadian clock and homeostasis in skeletal muscle and bone via hormonal cues, the nervous system, locomotor activity and feeding behavior. Muscular clocks are regulated by scheduled exercise in an SCN-independent manner. Circadian variation of osseous markers are regulated by scheduled feeding.
See this image and copyright information in PMC

References

    1. Andrews J. L., Zhang X., McCarthy J. J., McDearmon E. L., Hornberger T. A., Russell B., et al. . (2010). CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc. Natl. Acad. Sci. U.S.A. 107, 19090–19095. 10.1073/pnas.1014523107 - DOI - PMC - PubMed
    1. Bae K., Lee K., Seo Y., Lee H., Kim D., Choi I. (2006). Differential effects of two period genes on the physiology and proteomic profiles of mouse anterior tibialis muscles. Mol. Cells 22, 275–284. - PubMed
    1. Balsalobre A., Brown S. A., Marcacci L., Tronche F., Kellendonk C., Reichardt H. M., et al. . (2000). Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289, 2344–2347. 10.1126/science.289.5488.2344 - DOI - PubMed
    1. Barger L. K., Wright K. P., Jr., Hughes R. J., Czeisler C. A. (2004). Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R1077–R1084. 10.1152/ajpregu.00397.2003 - DOI - PubMed
    1. Becker-Andre M., Andre E., DeLamarter J. F. (1993). Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. Biochem. Biophys. Res. Commun. 194, 1371–1379. - PubMed

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