Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Dec;75(12):5893-7.
doi: 10.1073/pnas.75.12.5893.

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA

P J Farrell, G C Sen, M F Dubois, L Ratner, E Slattery, P Lengyel

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA

P J Farrell et al. Proc Natl Acad Sci U S A. 1978 Dec.

Abstract

Double-stranded RNA inhibits protein synthesis in at least two ways. It activates a protein kinase that blocks peptide chain initiation by phosphorylating the peptide chain initiation factor eIF-2 and also activates an endonuclease that inactivates different mRNAs at different rates. The protein kinase and the endonuclease have been partially purified from interferon-treated Ehrlich ascites tumor cells. The 2',5'-oligoadenylates [pppA(2'p5'A)n], found found earlier to be mediators in the activation of the endonuclease by double-stranded RNA, are not mediators in the activation of the protein kinase by double-stranded RNA.

PubMed Disclaimer

References

    1. Eur J Biochem. 1978 Mar;84(1):149-59 - PubMed
    1. J Biol Chem. 1975 Dec 10;250(23):9067-75 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1167-71 - PubMed
    1. Cell. 1978 Mar;13(3):565-72 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Jan;75(1):256-60 - PubMed

Publication types

MeSH terms

LinkOut - more resources