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. 2017 Feb 10;8(3):403-409.
doi: 10.7150/jca.17028. eCollection 2017.

Plasma Fibrinogen Correlates with Metastasis and is Associated with Prognosis in Human Nasopharyngeal Carcinoma

Sha-Sha He  1 , Yan Wang  1 , Lin Yang  1 , Hai-Yang Chen  2 , Shao-Bo Liang  3 , Li-Xia Lu  1 , Yong Chen  1
Affiliations

Plasma Fibrinogen Correlates with Metastasis and is Associated with Prognosis in Human Nasopharyngeal Carcinoma

Sha-Sha He et al. J Cancer. .

Abstract

Background: The purpose of this observational study was to evaluate the prognostic significance of the pre-treatment plasma fibrinogen level for survival outcomes in nasopharyngeal carcinoma (NPC). Methods: A total of 998 patients with NPC treated at a single centre in China were retrospectively enrolled, of whom 182 (18.2%) developed distant metastasis during follow-up. Survival analyses were performed by the Kaplan-Meier method and Cox regression modelling to measure 3-year overall survival (OS) and distant metastasis-free survival (DMFS). Results: Median OS for the entire cohort was 37.8 months. Using the cut-off value of 3.345 g/L identified in receiver operating curve analysis for fibrinogen, a high pre-treatment plasma fibrinogen level were associated with older age (P = 0.034), advanced TNM stage (P = 0.004) and development of distant metastasis (P < 0.001; Chi-square test). Multivariate Cox proportional hazard analysis demonstrated the pre-treatment plasma fibrinogen level was an independent significant prognostic factor for OS and DMFS in both the entire cohort and also among patients who developed distant metastasis during follow-up. Conclusions: This study suggests the pre-treatment plasma fibrinogen level may serve as an independent prognostic marker to predict the survival outcomes of patients with NPC, including patients with metastatic disease.

Keywords: Nasopharyngeal carcinoma; fibrinogen; metastasis; prognosis..

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Kaplan-Meier overall survival (A) and distant metastasis-free survival (B) curves for all 998 patients with NPC stratified by pre-treatment plasma fibrinogen level (≥ 3.345 g/L vs. < 3.345 g/L).
Figure 2
Figure 2
Kaplan-Meier overall survival curves for the patients who developed metastasis during follow-up stratified by pre-treatment plasma fibrinogen level (≥ 3.345 g/L vs. < 3.345 g/L). (A) All patients with distant metastasis; (B) patients with bone metastasis; (C) patients with lung metastasis; (D) patients with liver metastasis.
See this image and copyright information in PMC

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