Impact of haemostatic mechanisms on pathophysiology of preeclampsia

Abstract

Preeclampsia (PE) is disorder of new onset hypertension and proteinuria during the second half of pregnancy. There is increasing evidence to implicate placental over-expression of tissue factor and PAR-1 in the pathophysiology of PE. Excessive activation of platelets, neutrophils and the complement system may also contribute to the placental pathology and maternal endothelial responsible for the symptoms of PE. Increased knowledge in this field may identify new therapeutic strategies for the treatment of PE.

Keywords: Haemostasis; Platelets; Preeclampsia; Syncytiotrophoblast; Tissue factor.