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. 1987 Dec 21;226(1):176-8.
doi: 10.1016/0014-5793(87)80574-4.

A second catalytic subunit of type-2A protein phosphatase from rabbit skeletal muscle

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A second catalytic subunit of type-2A protein phosphatase from rabbit skeletal muscle

O B da Cruz e Silva et al. FEBS Lett. .
Free article

Abstract

A cDNA clone encoding a second type-2A protein phosphatase catalytic subunit (2A beta) was isolated from a rabbit skeletal muscle cDNA library constructed in lambda gt10. The deduced protein sequence (309 residues, 35.59 kDa) was 97% identical to that of phosphatase 2A alpha (309 residues, 35.58 kDa). At the nucleotide level, the two clones showed only 82% identity in the coding region. The results indicate the presence of at least two isoforms of protein phosphatase 2A in skeletal muscle.

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