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. 1978 Dec;75(12):6098-101.
doi: 10.1073/pnas.75.12.6098.

Ten-nanometer filaments of hamster BHK-21 cells and epidermal keratin filaments have similar structures

P M Steinert, S B Zimmerman, J M Starger, R D Goldman

Ten-nanometer filaments of hamster BHK-21 cells and epidermal keratin filaments have similar structures

P M Steinert et al. Proc Natl Acad Sci U S A. 1978 Dec.

Abstract

The 10-nm filaments of baby hamster kidney (BHK-21) cells, when examined either in the form of native filament caps or polymerized in vitro, are long tubes of protein 8--10 nm in diameter. They contain about 42% alpha-helix, which, on the basis of x-ray diffraction data, is arranged in a coiled-coil conformation characteristic of proteins of the alpha type. The known structural properties such as morphology, dimensions, subunit composition, and ultrastructure of this fibrous protein are very similar to those of the mammalian epidermal keratin filament, to which it may therefore be related.

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