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Comment
. 2017 Apr;13(4):195-196.
doi: 10.1038/nrneph.2017.21. Epub 2017 Mar 6.

Hypertension: From GWAS to functional genomics-based precision medicine

David L Mattson  1 , Mingyu Liang  1
Affiliations
Comment

Hypertension: From GWAS to functional genomics-based precision medicine

David L Mattson et al. Nat Rev Nephrol. 2017 Apr.

Abstract

Several recent studies have provided insights into the genetic regulation of blood pressure. A new study extends these findings by coupling genome-wide association study data with functional validation approaches to identify and explore loci associated with blood pressure, generating a genetic risk score model to predict future cardiovascular risk

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Conflict of interest statement

Competing interests

The authors declare no competing interests

Figures

Figure 1
Figure 1
Functional genomics in disease-relevant tissues is essential for advancing the precision medicine for common and complex diseases.
See this image and copyright information in PMC

Comment on

  • Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
    Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MP, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Mägi R, Stanton A, Connell J, Bakker SJ, Metspalu A, Shields DC, Thom S, Brown M, Sever P, Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D, Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JM, Tobin MD, Munroe PB, Ehret GB, Wain LV; International Consortium of Blood Pressure (ICBP) 1000G Analyses; BIOS Consortium; Lifelines Cohort Study; Understanding Society Scientific group; CHD Exome+ Consortium; ExomeBP Consortium; T2D-GENES Consortium; GoT2DGenes Consortium; Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; UK Biobank CardioMetabolic Consortium BP working group. Warren HR, et al. Nat Genet. 2017 Mar;49(3):403-415. doi: 10.1038/ng.3768. Epub 2017 Jan 30. Nat Genet. 2017. PMID: 28135244 Free PMC article.

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