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. 2017 Mar 6:7:43907.
doi: 10.1038/srep43907.

Prognostic factors of palatal mucoepidermoid carcinoma: a retrospective analysis based on a double-center study

Wenguang Xu  1   2 , Yufeng Wang  1   2 , Xiaofeng Qi  1   2 , Junqi Xie  1   2 , Zheng Wei  1   2 , Xiteng Yin  1   2 , Zhiyong Wang  1   2 , Jian Meng  3 , Wei Han  1   2
Affiliations

Prognostic factors of palatal mucoepidermoid carcinoma: a retrospective analysis based on a double-center study

Wenguang Xu et al. Sci Rep. .

Abstract

Mucoepidermoid carcinoma (MEC) of the palate is a common malignancy of minor salivary glands. This study was designed to identify the prognostic factors for MEC of the palate. The medical records of patients diagnosed with MEC of the palate who visited the Department of Oral and Maxillofacial Surgery at Nanjing Stomatological Hospital and the Department of Stomatology at Central Hospital of Xuzhou were retrospectively studied. The prognostic factors were determined using a Cox proportional hazards model. Furthermore, the expression of cancer stem cell (CSC) markers CD44, CD133, Nanog and Sox2 were detected in neoplastic samples of these patients by immunohistochemistry. As a result, both univariate analysis and multivariate analysis proved a high histological grade and an advanced tumor stage as negative prognostic factors for overall survival. By immunohistochemistry staining and survival analysis, a combination of CD44/CD133/SOX2 was found to have the strongest prognostic value for palatal MEC patients. In conclusion, the proposed nomogram which include histological grade and tumor stage along with cancer stem cell markers provides a more accurate long-term prediction for palatal MEC patients.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Overall survival estimated by histological grade (A) and tumor stage (B) for the 75 patients with MEC of the palate.
Figure 2
Figure 2. Nomogram including histological grade and tumor stage for predicting 3-year, 5-year and 10-year OS for palatal MEC patients.
Figure 3
Figure 3
Immunohistochemical staining for CD44 (A), CD133 (B), SOX2 (C) and Nanog (D) in palatal MEC tissues.
Figure 4
Figure 4
Kaplan–Meier curves estimated by the expression of CD44 (A), CD133 (B), SOX2 (C) and Nanog (D).
Figure 5
Figure 5
Kaplan–Meier curves estimated by various combination of markers, CD44/CD133 (A), CD44/SOX2 (B), CD44/Nanog (C), CD133/SOX2 (D), CD133/Nanog (E), SOX2/Nanog (F), CD44/CD133/Nanog (G).
Figure 6
Figure 6. Nomogram including histological grade and tumor stage along with CD44/CD133/Nanog expression for predicting 3-year, 5-year and 10-year OS for palatal MEC patients.
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