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Meta-Analysis
. 2017 May;8(3):203-213.
doi: 10.1111/1759-7714.12425. Epub 2017 Mar 6.

Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis

Yongsheng Zhao  1   2 , Renyan Zheng  2 , Jian Li  1 , Feng Lin  1 , Lunxu Liu  1
Affiliations
Meta-Analysis

Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis

Yongsheng Zhao et al. Thorac Cancer. 2017 May.

Abstract

Background: Phosphatase and tensin homolog ( PTEN ), regarded as a tumor suppressor gene, may act as a prognostic biomarker in human cancers.

Methods: All eligible studies from MEDLINE, Embase, CENTRAL, and the Chinese BioMedical Literature Database to October 2016 were incorporated. Two reviewers independently screened the literature according to inclusion and exclusion criteria, extracted the data, assessed the methodological quality of the included studies, and conducted meta-analysis.

Results: A total of 2486 patients from 19 studies were included. PTEN expression was significantly correlated with gender, smoking history, histology (adenocarcinoma [ADC] vs. squamous cell carcinoma), tumor node metastasis stage (I-II vs. III-IV), N status (N0 vs. N1-N3), and distant metastasis (M0 vs. M1). Loss of PTEN expression was associated with poorer overall survival, but had no significant association with disease-free survival. Subgroup analysis showed that negative PTEN expression was associated with a poorer outcome in Asian and ADC patients, but not in Western or squamous cell carcinoma patients.

Conclusion: Loss of PTEN might play an unfavorable prognostic role for overall survival of non-small cell lung cancer patients, especially Asian or ADC patients.

Keywords: Meta-analysis; non-small cell lung cancer; phosphatase and tensin homolog; prognosis.

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Figures

Figure 1
Figure 1
PubMed search strategy. PTEN, phosphatase and tensin homolog.
Figure 2
Figure 2
Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) flow diagram for selection of studies. HR, hazard ratio; PTEN, phosphatase and tensin homolog.
Figure 3
Figure 3
Pooled hazard ratios (HRs) for assessing the prognostic value of phosphatase and tensin homolog expression for overall survival in (a) non‐small cell lung cancer, (b) adenocarcinoma, and (c) squamous cell carcinoma. †Patients treated with chemotherapy; ‡patients treated with chemotherapy + cetuximab. CI, confidence interval; D+L, DerSimonian & Laird; I–V, inverse variance.
Figure 4
Figure 4
Pooled hazard ratios (HRs) for assessing the prognostic value of PTEN expression for DFS in surgical patients.
Figure 5
Figure 5
Publication bias of the prognostic value of phosphatase and tensin homolog for overall survival in non‐small cell lung cancer on Begg's and Egger's plots. SE, standard error.
See this image and copyright information in PMC

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