Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;170(1):442-5.
doi: 10.1128/jb.170.1.442-445.1988.

Drug-induced relaxation of supercoiled plasmid DNA in Bacillus subtilis and induction of the SOS response

M S Osburne  1 , S M Zavodny, G A Peterson
Affiliations

Drug-induced relaxation of supercoiled plasmid DNA in Bacillus subtilis and induction of the SOS response

M S Osburne et al. J Bacteriol. 1988 Jan.

Abstract

Whereas treatment with many different drugs led to induction of the SOS response in Bacillus subtilis, only inhibitors of DNA gyrase subunit B and, unexpectedly, polyether antibiotics (membrane ionophores) led to relaxation of supercoiled plasmid DNA. However, treatment with DNA gyrase subunit B inhibitors but not with polyethers led to SOS induction. Thus, the presence of underwound supercoiled DNA was not sufficient to induce the SOS response. Possible mechanisms by which polyethers induce relaxation of supercoiled DNA in vivo are discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Mol Biol. 1978 Apr 5;120(2):145-54 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1423-7 - PubMed
    1. J Bacteriol. 1979 Jan;137(1):635-43 - PubMed
    1. J Bacteriol. 1980 Mar;141(3):1331-9 - PubMed
    1. Mol Gen Genet. 1980 Apr;178(1):233-5 - PubMed

MeSH terms

LinkOut - more resources