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Review
. 2017 Feb 27;22(3):368.
doi: 10.3390/molecules22030368.

The Pharmaceutical Industry in 2016. An Analysis of FDA Drug Approvals from a Perspective of the Molecule Type

Beatriz G de la Torre  1 , Fernando Albericio  2   3   4
Affiliations
Review

The Pharmaceutical Industry in 2016. An Analysis of FDA Drug Approvals from a Perspective of the Molecule Type

Beatriz G de la Torre et al. Molecules. .

Abstract

This is an analysis from a chemical point of view of the 22 drugs accepted by the FDA during 2016. The different drugs from the 2016 "harvest" have been classified according to their chemical structure: antibodies; TIDES (oligonucleotides and peptides); amino acids and natural products; drug combination; and small molecules.

Keywords: API; biologics; chemical entities; drug discovery; peptide; small molecules.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
New Chemical Entities and Biologics approved by the FDA in the last two decades [3,4].
Figure 2
Figure 2
General structure of oligonucleotide-based drugs. Standard RNA strand (A); Phosphorothioate backbone (B); Morpholino Phosphorodiamidate backbone (C); Standard DNA strand (D).
Figure 3
Figure 3
Structure of Adlyxin.
Figure 4
Figure 4
Structures of Xiidra (A); Briviact (B); Auxim (C); and Ocaliva (D).
Figure 5
Figure 5
Structures and composition of Zepatier (A) and Epclusa (B).
Figure 6
Figure 6
Structures of Rubraca (A); Eucrisa (B); Nuplazid (C); and Venclexta (D).
See this image and copyright information in PMC

References

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    1. Jarvis L.M. The Year in New Drugs. Chemical & Engineering News; Washington, DC, USA: 2017. pp. 28–32.

MeSH terms