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. 2017 Feb 28;8(1):8.
doi: 10.3390/jfb8010008.

Fabrication and Optimal Design of Biodegradable Polymeric Stents for Aneurysms Treatments

Xue Han  1 , Xia Wu  2 , Michael Kelly  3 , Xiongbiao Chen  4   5
Affiliations

Fabrication and Optimal Design of Biodegradable Polymeric Stents for Aneurysms Treatments

Xue Han et al. J Funct Biomater. .

Abstract

An aneurysm is a balloon-like bulge in the wall of blood vessels, occurring in major arteries of the heart and brain. Biodegradable polymeric stent-assisted coiling is expected to be the ideal treatment of wide-neck complex aneurysms. This paper presents the development of methods to fabricate and optimally design biodegradable polymeric stents for aneurysms treatment. Firstly, a dispensing-based rapid prototyping (DBRP) system was developed to fabricate coil and zigzag structures of biodegradable polymeric stents. Then, compression testing was carried out to characterize the radial deformation of the stents fabricated with the coil or zigzag structure. The results illustrated the stent with a zigzag structure has a stronger radial stiffness than the one with a coil structure. On this basis, the stent with a zigzag structure was chosen for the development of a finite element model for simulating the real compression tests. The result showed the finite element model of biodegradable polymeric stents is acceptable within a range of radial deformation around 20%. Furthermore, the optimization of the zigzag structure was performed with ANSYS DesignXplorer, and the results indicated that the total deformation could be decreased by 35.7% by optimizing the structure parameters, which would represent a significant advance of the radial stiffness of biodegradable polymeric stents.

Keywords: biodegradable polymeric stents; fabrication; optimization; radial stiffness; simulation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Picture of fabrication setting. (a) Schematic of fabrication of biodegradable stents. (b) Fabrication system.
Figure 2
Figure 2
Structures of biodegradable polymeric stents. (a) Coil structure. (b) Zigzag structure.
Figure 3
Figure 3
Compression tests for biodegradable polymeric stents. (a) Bose ElectroForce Biodynamic testing system. (b) Loading plates for specimen.
Figure 4
Figure 4
Simulation of compression test. (a) Mesh. (b) Fixed support on the upper plate. (c) Fixed support on the upper plate. (d) Force applied on the lower plate.
Figure 5
Figure 5
Model of biodegradable polymeric stents built in Pro/Engineer. (a) Parameters for each cell of zigzag biodegradable stents. (b) 3D model of zigzag biodegradable polymeric stent.
Figure 6
Figure 6
10% radial compression of biodegradable polymeric stents.
Figure 7
Figure 7
20% radial compression of biodegradable polymeric stents.
Figure 8
Figure 8
30% radial compression of biodegradable polymeric stents.
Figure 9
Figure 9
40% radial compression of biodegradable polymeric stents.
Figure 10
Figure 10
Deformation of compressing biodegradable polymeric stents radially 10% (a) and 20% (b).
Figure 11
Figure 11
Total deformation and force relationship comparison between FEA and real compression test.
Figure 12
Figure 12
Optimization results of biodegradable polymeric stents.
See this image and copyright information in PMC

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