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. 2017 Jan-Feb;7(1):37-45.

Anti-inflammatory effect of Fumaria parviflora leaves based on TNF-α, IL-1, IL-6 and antioxidant potential

Waseem Rizvi  1 , Mohammad Fayazuddin  2 , Ompal Singh  3 , Shariq Naeem Syed  1 , Shagufta Moin  4 , Kafil Akhtar  5 , Anil Kumar  1
Affiliations

Anti-inflammatory effect of Fumaria parviflora leaves based on TNF-α, IL-1, IL-6 and antioxidant potential

Waseem Rizvi et al. Avicenna J Phytomed. 2017 Jan-Feb.

Abstract

Objective: In this study, we evaluated anti-inflammatory activity of leaves of Fumaria parviflora (F. parviflora) and underlying mechanisms by using in vivo models of inflammation.

Material and methods: Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extracts of leaves of F. parviflora (EFP and AFP) were prepared. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as TNF-α, IL-6 and IL-1 and activity of antioxidant enzymes including catalase (CAT) and glutathione peroxidase (GPx) were estimated.

Results: Leaves of F. parviflora demonstrated significant (p<0.001) decrease in paw edema in carrageenan-induced paw edema method. It diminished the serum tumour necrosis factor-α (TNF-α), IL-6 and IL-1 levels and also significantly attenuated the malondialdehyde (MDA) levels. The activity of CAT and GPx was increased in paw tissue. It also demonstrated significant decrease in granuloma formation in cotton pellet-induced granuloma method.

Conclusion: Leaves of F. parviflora possess anti-inflammatory activity as they inhibit various cytokines and have antioxidant effects and free radical scavenging activity.

Keywords: Anti-inflammatory; Antioxidant; Carrageenan; Cytokines; Fumeria parviflora.

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Figures

Figure 1.
Figure 1.
Histological examination of paw sections 3 hr after carrageenan injection. (a) Control, (b) aspirin group, (c) aqueous extract group(500mg/kg),(d) ethanolic extract group(500mg/kg) at 400X
Figure 2
Figure 2
Effect of F. parviflora leaf extract on neutrophil infiltration in rat paw after carrageenan injection. Values are expressed as mean ± standard error of the mean. *p< 0.05, ** p< 0.001 when compared to the control group. EFP 500mg/kg; AFP 500mg/kg.
Figure 3
Figure 3
Effect of F. parviflora leaf extract on dry weight of cotton pellet granuloma.
See this image and copyright information in PMC

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