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. 2017 Sep;64(9).
doi: 10.1002/pbc.26489. Epub 2017 Mar 6.

Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review

Joanna E Fardell  1   2 , Janine Vetsch  1   2   3 , T Trahair  1   4 , M K Mateos  1   4 , M A Grootenhuis  5 , L M Touyz  1   2 , G M Marshall  1   4 , C E Wakefield  1   2
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Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review

Joanna E Fardell et al. Pediatr Blood Cancer. 2017 Sep.

Abstract

Children with acute lymphoblastic leukemia (ALL) undergo intense anticancer treatment. We systematically reviewed 22 studies evaluating 2,073 ALL patients' health-related quality of life (HRQL) and its clinical/demographic correlates during treatment. Overall HRQL was significantly reduced on treatment. Despite HRQL improvements over time, longitudinal studies reported a proportion of children continued to experience reduced HRQL after treatment completion. We found inconsistent associations between clinical/demographic factors and HRQL outcomes. Tentative evidence emerged for worse HRQL being associated with intensive phases of chemotherapy, corticosteroid therapy, experiencing greater toxicity, older age, and female sex. Longitudinal studies are needed to identify children at-risk of reduced HRQL.

Keywords: acute lymphoblastic leukemia; pediatric oncology; quality of life; systematic review; treatment.

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