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Comment
. 2017 May;27(5):602-603.
doi: 10.1038/cr.2017.28. Epub 2017 Mar 7.

Proteasomes on the chromosome

Michael Lichten  1
Affiliations
Comment

Proteasomes on the chromosome

Michael Lichten. Cell Res. 2017 May.

Abstract

Targeted proteolysis plays an important role in the execution and regulation of many cellular events. Two recent papers in Science identify novel roles for proteasome-mediated proteolysis in homologous chromosome pairing, recombination, and segregation during meiosis.

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Figures

Figure 1
Figure 1
(A) The budding yeast 26S proteasome (red) disassembles synaptonemal complex at sites of nonhomologous synapsis between centromeres, freeing up homologs to pair and synapse. The proteasome may also remove synaptonemal complex from other sites of nonhomologous synapsis. (B) Recombination nodule (RN) dynamics in male mouse meiosis. RNF212 (blue)-catalyzed SUMOylation stabilizes RNs and recombination intermediates, promoting homolog pairing, but also recruits HEI10 (purple). HEI10 ubiquitylates yet-to-be determined targets in RNs to recruit the 26S proteasome, destabilizing most RNs; at a subset of RNs, RNF212 activity dominates. These RNs perdure and the recombination intermediates that they contain are resolved as crossovers.
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Comment on

References

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