Mouse ovarian tumors--a review including classification and induction of neoplastic lesions and description of several previously unreported types

Abstract

The purpose of this study is to review the pertinent literature on the incidence, methods of induction and pathogenesis of ovarian tumors of mice. Strains of mice with a high incidence of spontaneously occurring granulosa cell tumors (gct) and tubular adenomas (ta) are the C3HeB/Fe and C3HeB/De; strain HAN:NMRI developed Sertoli cell tumors and (DBA x Ce)F1 hybrids had a high incidence gct. Ninety-five percent of hybrid (C57BL/6J x C3H/HeJ)F1 WxWv mice which lack germ cells develop complex tubular adenomas. Strain LT, in which a high percentage of ovarian ova develop parthenogenetically, develops has a high incidence of teratomas. The use of hormones, castration and transplantation of the ovaries in a number of inbred strains results in a high incidence of ovarian tumors; in strain Maf/Sp gct and luteomas were induced in 82%. Irradiation with gamma rays produced a similar incidence of ovarian tumors in (C57L x A)F1 hybrids. The chemical inducing the highest incidence (92%) of ovarian tumors of mice is 9,10 Dimethyl 1,2 benzanthracene (DMBA). Recently, 4-Vinylcyclohexene was shown to induce a high incidence of ovarian tumors. A number of rare ovarian tumors were reported. Described are five androblastomas composed of either Leydig or Sertoli cells or a combination of the two cell types and a single undifferentiated androblastoma. Seven teratomas were described, three of which contained large amounts of neural tissue; another was classified as a teratoma with a parieto-visceral yolk-sac carcinoma component.