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. 2017 Mar 16;35(3):143-151.
doi: 10.1080/07357907.2017.1289216. Epub 2017 Mar 7.

CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas

Salla Haimakainen  1 , Antti P Kaukinen  1 , Mireille-Maria Suttle  1 , Jukka Pelkonen  2 , Ilkka T Harvima  1
Affiliations

CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas

Salla Haimakainen et al. Cancer Invest. .

Abstract

The expression of CD40 ligand (CD40L) in mast cells was investigated in biopsies from lesional and non-lesional skin samples of patients with psoriasis, actinic keratosis (AK), basal cell carcinoma, and squamous cell carcinoma using a sequential double-staining technique. The percentage of CD40L+ mast cells was higher in the lesional than in the non-lesional skin (p < .003). Interestingly, this percentage was lower in both carcinomas than in psoriasis and actinic keratosis (p < .025). Cells immunopositive for CD40 receptor were increased in all lesion types but especially so in carcinomas. The results suggest a dysregulated anti-tumoral immune response by mast cell CD40L in skin carcinomas.

Keywords: Actinic keratosis; CD40 ligand; mast cell; psoriasis; skin carcinoma.

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