Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Feb;62(2):629-32.
doi: 10.1128/JVI.62.2.629-632.1988.

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors

C Pasquinelli  1 , F Garreau, L Bougueleret, E Cariani, K H Grzeschik, V Thiers, O Croissant, M Hadchouel, P Tiollais, C Bréchot
Affiliations

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors

C Pasquinelli et al. J Virol. 1988 Feb.

Abstract

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be implicated in the formation of different tumors at one step of liver cell transformation, possibly related to HBV integration.

PubMed Disclaimer

References

    1. Nature. 1980 Jul 31;286(5772):533-5 - PubMed
    1. Nucleic Acids Res. 1986 Nov 11;14(21):8373-86 - PubMed
    1. J Virol. 1980 Feb;33(2):795-806 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 May;80(9):2505-9 - PubMed
    1. Cell. 1983 Jul;33(3):717-28 - PubMed

Publication types