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. 2016 Aug:2016:1463-1466.
doi: 10.1109/EMBC.2016.7590985.

Host-aware modelling of a synthetic genetic oscillator

Alexander Darlington, Declan G Bates

Host-aware modelling of a synthetic genetic oscillator

Alexander Darlington et al. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug.

Abstract

Synthetic genetic circuits sometimes exhibit unexpected functionality or even fail entirely when implemented in vivo, due to the effects of interactions with the host cell that were not accounted for in the circuit's design. In this paper, we consider the effects that limitations in cellular resources have on the dynamics of a synthetic cellular oscillator. We show that incorporating these effects into a host-aware model of the synthetic oscillator results in significant changes in its dynamics, highlighting the need to take account of host-circuit interactions in mathematical models that are to be used as CAD tools for synthetic circuitry.

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