Integration of SNPs-FMRI-methylation data with sparse multi-CCA for schizophrenia study

Abstract

Schizophrenia (SZ) is a complex mental disorder associated with genetic variations, brain development and activities, and environmental factors. There is an increasing interest in combining genetic, epigenetic and neuroimaging datasets to explore different level of biomarkers for the correlation and interaction between these diverse factors. Sparse Multi-Canonical Correlation Analysis (sMCCA) is a powerful tool that can analyze the correlation of three or more datasets. In this paper, we propose the sMCCA model for imaging genomics study. We show the advantage of sMCCA over sparse CCA (sCCA) through the simulation testing, and further apply it to the analysis of real data (SNPs, fMRI and methylation) from schizophrenia study. Some new genes and brain regions related to SZ disease are discovered by sMCCA and the relationships among these biomarkers are further discussed.