Of nerves and stomach cancer

Affiliations

Comment

Leslie K Ferrarelli. Sci Signal. 2017.

. 2017 Mar 7;10(469):eaan0914.

doi: 10.1126/scisignal.aan0914.

Abstract

Blocking a feed-forward cholinergic loop between gastric neurons and the mucosal epithelium may inhibit proliferation in tumor-associated stem cells.

Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC. Hayakawa Y, et al. Cancer Cell. 2017 Jan 9;31(1):21-34. doi: 10.1016/j.ccell.2016.11.005. Epub 2016 Dec 15. Cancer Cell. 2017. PMID: 27989802 Free PMC article.
Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer.
Monje M. Monje M. Cancer Cell. 2017 Jan 9;31(1):1-2. doi: 10.1016/j.ccell.2016.12.008. Cancer Cell. 2017. PMID: 28073000