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Review
. 2017 May;18(5):331-337.
doi: 10.1038/nrm.2017.12. Epub 2017 Mar 8.

Regulatory feedback from nascent RNA to chromatin and transcription

Lenka Skalska  1 , Manuel Beltran-Nebot  1 , Jernej Ule  2 , Richard G Jenner  1
Affiliations
Free article
Review

Regulatory feedback from nascent RNA to chromatin and transcription

Lenka Skalska et al. Nat Rev Mol Cell Biol. 2017 May.
Free article

Erratum in

Abstract

Transcription and chromatin function are regulated by proteins that bind to DNA, nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. Unlike ncRNAs, nascent pre-mRNA was considered to be primarily a passive player in these processes. In this Opinion article, we describe recently identified interactions between nascent pre-mRNAs and regulatory proteins, highlight commonalities between the functions of nascent pre-mRNA and nascent ncRNA, and propose that both types of RNA have an active role in transcription and chromatin regulation.

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