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. 2017 Jun;31(6):1460-1463.
doi: 10.1038/leu.2017.76. Epub 2017 Mar 8.

Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents

M Poganitsch-Korhonen  1 , I Masliukaite  2 , M Nurmio  3   4 , P Lähteenmäki  4 , M van Wely  2 , A M M van Pelt  2 , K Jahnukainen  1   5 , J-B Stukenborg  5
Affiliations

Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents

M Poganitsch-Korhonen et al. Leukemia. 2017 Jun.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Numbers of spermatogonia per transverse tubular cross-section (S/T) of leukaemic boys exposed to chemotherapy with (red dots) and without (blue dots) alkylating agents or irradiation (triangle). (a) S/T values after completion of induction therapy and after cessation of ALL therapy (red and blue dots) plotted on a meta-regression fit line of S/T reference values throughout healthy prepuberty*. Samples with leukaemic infiltration are marked L. (b) Regression analysis of S/T values among patients up to 12 years of age. Values of S/T among patients not exposed to alkylating agents (blue dots) show a gradual increase until the age of 6–7 years and a plateau thereafter, whereas S/T values in patients exposed to alkylating agents (red dots) display a continuous decline from the age of 4 to 5 years. (c) Values of S/T among patients treated with alkylating agents show a plateau at values close to zero with cumulative cyclophosphamide equivalent doses >4000 mg/m2. *Modified from Masliukaite et al. Copyright (2016), with permission from Elsevier. This article is published under the terms of the Creative Commons Attribution-NonCommercial-No Derivatives License (CC BY NC ND) https://creativecommons.org/licenses/by-nc-nd/4.0/.
See this image and copyright information in PMC

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