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Review
. 2017 Jan;14(1):67-72.
doi: 10.11909/j.issn.1671-5411.2017.01.006.

New generations of dihydropyridines for treatment of hypertension

Angela L Wang  1 , Costantino Iadecola  2 , Gang Wang  2
Affiliations
Review

New generations of dihydropyridines for treatment of hypertension

Angela L Wang et al. J Geriatr Cardiol. 2017 Jan.

Abstract

Since the calcium channel blocker (CCB) has become one of the most prescribed agents for antihypertensive monotherapy in the world, this brief review will focus on the recent research and development of the dihydropyridine (DHP) CCB, addressing pharmacological mechanisms for the clinical efficacy of the third and fourth generations of the DHP CCBs, especially on their possible central mechanisms underlying lowering blood pressure.

Keywords: Central nervous system; Dihydropyridine; Hypertension; Voltage-gated calcium channel blocker.

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