Meta-Analysis

. 2017 Sep;27(3):245-257.

doi: 10.1007/s11065-017-9342-8. Epub 2017 Mar 7.

Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

Colette M Smart^{1

2}, Justin E Karr³, Corson N Areshenkoff³, Laura A Rabin⁴, Carol Hudon^{5

6}, Nicola Gates⁷, Jordan I Ali³, Eider M Arenaza-Urquijo^{8

9

10

11}, Rachel F Buckley^{12

13

14}, Gael Chetelat^{8

9

10

11}, Harald Hampel^{15

16}, Frank Jessen^{17

18}, Natalie L Marchant¹⁹, Sietske A M Sikkes²⁰, Andrea Tales²¹, Wiesje M van der Flier²⁰, Linda Wesselman²⁰; and the Subjective Cognitive Decline Initiative (SCD-I) Working Group

Affiliations

¹ Department of Psychology, University of Victoria, PO Box 1700, STN CSC, Victoria, BC, V8W 2Y2, Canada. csmart@uvic.ca.
² Institute on Aging and Lifelong Health, University of Victoria, Victoria, BC, Canada. csmart@uvic.ca.
³ Department of Psychology, University of Victoria, PO Box 1700, STN CSC, Victoria, BC, V8W 2Y2, Canada.
⁴ Brooklyn College and The Graduate Center of The City University of New York, New York, NY, USA.
⁵ Universite Laval, Quebec City, QC, Canada.
⁶ Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Quebec City, QC, Canada.
⁷ University of New South Wales, Sydney, Australia.
⁸ INSERM, U1077, 14074, Caen, France.
⁹ Université de Caen Basse-Normandie UMR-S1077, 14074, Caen, France.
¹⁰ Ecole Pratique des Hautes Etudes, UMR-S1077, 14074, Caen, France.
¹¹ CHU de Caen, U1077, 14000, Caen, France.
¹² Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
¹³ Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
¹⁴ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
¹⁵ AXA Research Fund and UPMC Chair, Sorbonne Universities, Pierre et Marie Curie University, Paris, France.
¹⁶ Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127, Department of Neurology, Pitié-Salpêtrière University Hospital, Paris, France.
¹⁷ Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.
¹⁸ German Center for Neurodegenerative Diseases (DZNE), Bonn/Cologne, Germany.
¹⁹ Division of Psychiatry, University College London, London, England, UK.
²⁰ Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
²¹ Swansea University, Swansea, Wales, UK.

PMID: 28271346
DOI: 10.1007/s11065-017-9342-8

Meta-Analysis

Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

Colette M Smart et al. Neuropsychol Rev. 2017 Sep.

. 2017 Sep;27(3):245-257.

doi: 10.1007/s11065-017-9342-8. Epub 2017 Mar 7.

Authors

Affiliations

¹ Department of Psychology, University of Victoria, PO Box 1700, STN CSC, Victoria, BC, V8W 2Y2, Canada. csmart@uvic.ca.
² Institute on Aging and Lifelong Health, University of Victoria, Victoria, BC, Canada. csmart@uvic.ca.
³ Department of Psychology, University of Victoria, PO Box 1700, STN CSC, Victoria, BC, V8W 2Y2, Canada.
⁴ Brooklyn College and The Graduate Center of The City University of New York, New York, NY, USA.
⁵ Universite Laval, Quebec City, QC, Canada.
⁶ Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Quebec City, QC, Canada.
⁷ University of New South Wales, Sydney, Australia.
⁸ INSERM, U1077, 14074, Caen, France.
⁹ Université de Caen Basse-Normandie UMR-S1077, 14074, Caen, France.
¹⁰ Ecole Pratique des Hautes Etudes, UMR-S1077, 14074, Caen, France.
¹¹ CHU de Caen, U1077, 14000, Caen, France.
¹² Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
¹³ Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
¹⁴ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
¹⁵ AXA Research Fund and UPMC Chair, Sorbonne Universities, Pierre et Marie Curie University, Paris, France.
¹⁶ Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127, Department of Neurology, Pitié-Salpêtrière University Hospital, Paris, France.
¹⁷ Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.
¹⁸ German Center for Neurodegenerative Diseases (DZNE), Bonn/Cologne, Germany.
¹⁹ Division of Psychiatry, University College London, London, England, UK.
²⁰ Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
²¹ Swansea University, Swansea, Wales, UK.

PMID: 28271346
DOI: 10.1007/s11065-017-9342-8

Abstract

In subjective cognitive decline (SCD), older adults present with concerns about self-perceived cognitive decline but are found to have clinically normal function. However, a significant proportion of those adults are subsequently found to develop mild cognitive impairment, Alzheimer's dementia or other neurocognitive disorder. In other cases, SCD may be associated with mood, personality, and physical health concerns. Regardless of etiology, adults with SCD may benefit from interventions that could enhance current function or slow incipient cognitive decline. The objective of this systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, is to examine the benefits of non-pharmacologic intervention (NPI) in persons with SCD. Inclusion criteria were studies of adults aged 55 + with SCD defined using published criteria, receiving NPI or any control condition, with cognitive, behavioural, or psychological outcomes in controlled trails. Published empirical studies were obtained through a standardized search of CINAHL Complete, Cochrane Central Register of Controlled Trials, MEDLINE with Full Text, PsycINFO, and PsycARTICLES, supplemented by a manual retrieval of relevant articles. Study quality and bias was determined using PEDro. Nine studies were included in the review and meta-analysis. A wide range of study quality was observed. Overall, a small effect size was found on cognitive outcomes, greater for cognitive versus other intervention types. The available evidence suggests that NPI may benefit current cognitive function in persons with SCD. Recommendations are provided to improve future trials of NPI in SCD.

Keywords: Alzheimer’s disease; Cognitive interventions; Complementary therapies; Mild cognitive impairment; Treatment outcome.

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Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

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Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

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