Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Dec;84(24):9270-4.
doi: 10.1073/pnas.84.24.9270.

Expression and rearrangement of the ROS1 gene in human glioblastoma cells

C Birchmeier  1 , S Sharma, M Wigler
Affiliations

Expression and rearrangement of the ROS1 gene in human glioblastoma cells

C Birchmeier et al. Proc Natl Acad Sci U S A. 1987 Dec.

Abstract

The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines. In a survey of 45 different human cell lines, we found ROS1 to be expressed in glioblastoma-derived cell lines at high levels and not to be expressed at all, or expressed at very low levels, in the remaining cell lines. The ROS1 gene was present in normal copy numbers in all cell lines that expressed the gene. However, in one particular glioblastoma line, we detected a potentially activating mutation at the ROS1 locus.

PubMed Disclaimer

References

    1. Science. 1977 Jun 17;196(4296):1313-9 - PubMed
    1. Mol Cell Biol. 1986 Sep;6(9):3109-16 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6 - PubMed
    1. Cell. 1983 Nov;35(1):71-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Jan;81(1):85-9 - PubMed

Publication types

LinkOut - more resources