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Case Reports
. 2017 Jul-Sep;63(3):194-196.
doi: 10.4103/0022-3859.201413.

Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16)

A Gupta  1 , G K Reddy  2 , M Goyal  1 , M R Kasaragadda  1
Affiliations
Case Reports

Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16)

A Gupta et al. J Postgrad Med. 2017 Jul-Sep.

Abstract

Erythrophagocytosis by leukemic blasts is a rare phenomenon. We report a case of a female diagnosed with acute monoblastic leukemia with leukemic blasts that were CD34 and CD117 negative, showing erythrophagocytosis, vacoulations, and a rare t(8;16) on bone marrow karyotype which is associated with a poor prognosis despite intensive chemotherapy. Meticulous bone marrow examination in such a scenario may point towards the presence of t(8;16) and help clinicians take a well-informed clinical decision.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Erythrophagocytosis by a monoblast showing an engulfed red blood cell (arrow mark, Leishman stain, and × 100 oil immersion)
Figure 2
Figure 2
Karyogram showing t(8;16) reported as per ISCN 2013 as 46, XX, t(8;16)(p11;p13)(20) (abnormal chromosomes 8 and 16 placed in the right side of their homolog chromosomes and marked with arrows, GTG staining and banding method × 100 oil immersion, processed using IKAROS software)
See this image and copyright information in PMC

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