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Comment
. 2017 Mar 7;25(3):486-488.
doi: 10.1016/j.cmet.2017.02.015.

Feeding the Genome: In Silico Optimization of Dietary Amino Acid Composition

Michael R MacArthur  1 , James R Mitchell  2
Affiliations
Comment

Feeding the Genome: In Silico Optimization of Dietary Amino Acid Composition

Michael R MacArthur et al. Cell Metab. .

Abstract

Optimizing dietary amino acid ratios to achieve maximal growth and reproduction has historically required tedious empirical studies. In this issue, Piper et al. (2017) present an in silico method of essential amino acid optimization based on the translated portion of an organism's genome, or exome.

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Figures

Figure 1
Figure 1. Effects of Essential Amino Acid Ratios at Different Levels of Protein Intake
Beneficial (a) or detrimental (r) effects on the indicated phenotypes of essential amino acids at ratios present in natural protein sources (meat and plant) versus organism-specific, exome-matched protein composition (exome matched) at high (top) or low (bottom) levels of total protein intake as indicated. Dashed lines represent dietary EAA requirements.
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