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Comment
. 2017 Mar 7;25(3):488-490.
doi: 10.1016/j.cmet.2017.02.014.

Should I Stay or Should I Go: A Clash of α-Cell Identity

Maria S Remedi  1
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Should I Stay or Should I Go: A Clash of α-Cell Identity

Maria S Remedi. Cell Metab. .
Free article

Abstract

Understanding mechanisms for maintaining pancreatic islet cell fate and function is important for addressing the urgent challenge of restoring islet β- and α-cell function in T1DM. In this issue of Cell Metabolism, Chakravarthy et al. (2017) identify a genetic mechanism by which mouse β-cells are spontaneously regenerated from adult α-cells.

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