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. 2017 Jan;11(1):ZC27-ZC32.
doi: 10.7860/JCDR/2017/21938.9169. Epub 2017 Jan 1.

Evaluation of Gengigel® Application in the Management of Furcation with Coronally Advanced Flap through Surgical Re-Entry-A Split Mouth Clinical Study

Sugandha Gupta  1 , Suresh D Kediege  2 , Akanksha Gupta  3 , Kanu Jain  4
Affiliations

Evaluation of Gengigel® Application in the Management of Furcation with Coronally Advanced Flap through Surgical Re-Entry-A Split Mouth Clinical Study

Sugandha Gupta et al. J Clin Diagn Res. 2017 Jan.

Abstract

Introduction: One of the challenging and unique periodontal problem of Grade II furcation defect has been managed through different treatment modalities in the past. A successful approach is based on complete closure of the defect. Different regenerative approaches have been tried.

Aim: This study was carried out with an aim to evaluate the role of Gengigel® (0.8% hyaluronic acid) as a potential material for regeneration of lost attachment apparatus.

Materials and methods: A total of 20 sites with Grade II furcation defects from 10 patients were selected using random sampling technique. These were divided into Group A (placement of hyaluronic acid) and Group B (without placement of hyaluronic acid) according to treatment modality. Furcation defect assessment was done in vertical and horizontal depth preoperatively and postoperatively at six months through surgical re-entry. Recorded data was subjected to the statistical analysis unpaired and paired t-tests for intergroup and intragroup comparisons respectively.

Results: Mean plaque index, gingival index and bleeding index score showed statistically highly significant and significant results respectively, for both the groups at baseline and six months. Mean difference in probing pocket depth and Relative Attachment Level (RAL) were statistically highly significant, whereas, mean difference of gingival position margin was non significant for both the groups, at baseline and six months. Mean difference in horizontal component at baseline and six months was statistically highly significant for both the groups. Mean difference in vertical component at baseline and six months was statistically significant for both the groups. On comparison, the mean difference in vertical and horizontal component of Group A and Group B at six months was statistically not significant.

Conclusion: Both Gengigel® with coronally positioned flap and coronally positioned flap alone are effective in the treatment of Grade II furcation defects. The combination of Gengigel® with coronally positioned flap leads to better results in hard tissue measurement as compared to coronally positioned flap alone.

Keywords: Hyaluronic acid; Periodontitis; Regeneration.

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Figures

[Table/Fig-1]
[Table/Fig-1]
Assessment of clinical parameters; a) Probing pocket depth; b) Relative clinical attachment level; c) Position of gingival margin.
[Table/Fig-2]
[Table/Fig-2]
Photograph showing surgical procedure: a) Sulcular incision; b) Defect site after debridement; c) Periosteal releasing incision; d) Root biomodification with 24% EDTA at neutral pH; e) Placement of GengigelⓇ (0.8% hyaluronic acid); f) Placement of sutures.
[Table/Fig-3]
[Table/Fig-3]
Assessment of vertical depth as A0 - B0 and horizontal depth as H0 at baseline: a) A0=RP to BF; b) B0=RP to FF; c) H0.
[Table/Fig-4]
[Table/Fig-4]
Assessment of a) Vertical depth as A6 - B6; b) Horizontal depth as H6, at six months postoperatively, through surgical re-entry.
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References

    1. Pontoriero R, Lindhe J, Nyman S, Karring T, Rosenberg E, Sanavi F. Guided tissue regeneration in the treatment of furcation defects in mandibular molars. A clinical study of degree III involvements. J Clin Periodontol. 1989;16(3):170–74. - PubMed
    1. Humagain M, Nayak DG, Uppoor AS. A clinical evaluation of bioactive glass particulate in the treatment of mandibular class II furcation defects. Braz J Oral Sci. 2007;6(23):1450–56.
    1. McFall WT., Jr Tooth loss in 100 treated patients with periodontal disease. A longterm study. J Periodontol. 1982;53(9):539–49. - PubMed
    1. Kalkwarf KL, Reinhardt RA. The furcation problem. Current controversies and future directions. Dent Clin North Am. 1988;32:243–66. - PubMed
    1. Reidy MEA, Yukna RA. Bone replacement grafts: The bone substitutes. Dent Clin North Am. 1998;42(3):491–504. - PubMed

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