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Editorial
. 2017 Sep;76(9):1481-1483.
doi: 10.1136/annrheumdis-2017-211109. Epub 2017 Mar 8.

The preclinical phase of PsA: a challenge for the epidemiologist

Editorial

The preclinical phase of PsA: a challenge for the epidemiologist

Alexis Ogdie. Ann Rheum Dis. 2017 Sep.
No abstract available

Keywords: Epidemiology; Outcomes research; Psoriatic Arthritis.

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Conflict of interest statement

Competing interests: AO has received support from an investigator-initiated research grant from Pfizer and has consulted for Novartis and Pfizer and has received payment for continuing medical education work related to psoriatic arthritis.

Figures

Figure 1
Figure 1
A preclinical phase of PsA likely includes an asymptomatic inflammatory phase followed by development of symptoms, and ultimately diagnosis. Kristensen et al demonstrated increasing comorbidities and societal economic costs in the 3 and 5 years prior to diagnosis, respectively. Disentangling the ‘preclinical phase’ of PsA from psoriasis is challenging. Furthermore, this preclinical phase makes assessment of comorbidities and risk factors challenging by impacting the interval over which risk factors and comorbidities may be assessed.

Comment on

References

    1. Ash ZR, Tinazzi I, Gallego CC, Kwok C, Wilson C, Goodfield M, et al. Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathythan those with normal nails. Ann Rheum Dis. 2012;71(4):553–6. - PubMed
    1. Freeston JE, Coates LC, Nam JL, Moverley AR, Hensor EM, Wakefield RJ, et al. Is there subclinical synovitis in early psoriatic arthritis? A clinical comparison with gray-scale and power Dopplerultrasound. Arthritis Care Res (Hoboken) 2014;66(3):432–9. - PMC - PubMed
    1. Offidani A, Cellini A, Valeri G, Giovagnoni A. Subclinical joint involvement in psoriasis: magnetic resonance imaging and X-ray findings. Acta Derm Venereol. 1998;78:463–5. - PubMed
    1. Faustini F, Simon D, Oliveira I, Kleyer A, Haschka J, Englbrecht M, et al. Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis. Ann Rheum Dis. 2016;75(12):2068–74. doi: 10.1136/annrheumdis-2015-208821. - DOI - PubMed
    1. McGonagle D, Ash Z, Dickie L, McDermott M, Aydin AZ. The early phase of psoriatic arthritis. Ann Rheum Dis. 2011;70(Suppl 1):i71–i6. - PubMed