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Comment
. 2017 May;55(5):1244-1248.
doi: 10.1128/JCM.00147-17. Epub 2017 Mar 8.

Strategies for Optimizing the Diagnostic Predictive Value of Clostridium difficile Molecular Diagnostics

Larry K Kociolek  1
Affiliations
Comment

Strategies for Optimizing the Diagnostic Predictive Value of Clostridium difficile Molecular Diagnostics

Larry K Kociolek. J Clin Microbiol. 2017 May.

Abstract

Because nucleic acid amplification tests (NAATs) do not distinguish Clostridium difficile infection (CDI) and asymptomatic C. difficile carriage, the diagnostic predictive value of NAATs is limited when used in patients with a low probability of CDI. In this issue of the Journal of Clinical Microbiology, Truong et al. (J. Clin. Microbiol., 55:1276-1284, 2017, https://doi.org/10.1128/JCM.02319-16) report significant reductions in hospital-onset CDI and oral vancomycin utilization at their institution following implementation of a novel intervention that leveraged their clinical bioinformatics resources to prevent C. difficile testing of stools from patients without clinically significant diarrhea and in patients with recent laxative use.

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References

    1. Emmadi R, Boonyaratanakornkit JB, Selvarangan R, Shyamala V, Zimmer BL, Williams L, Bryant B, Schutzbank T, Schoonmaker MM, Amos Wilson JA, Hall L, Pancholi P, Bernard K. 2011. Molecular methods and platforms for infectious diseases testing: a review of FDA-approved and cleared assays. J Mol Diagn 13:583–604. doi: 10.1016/j.jmoldx.2011.05.011. - DOI - PMC - PubMed
    1. Burnham CA, Carroll KC. 2013. Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories. Clin Microbiol Rev 26:604–630. doi: 10.1128/CMR.00016-13. - DOI - PMC - PubMed
    1. Kociolek LK, Gerding DN. 2016. Breakthroughs in the treatment and prevention of Clostridium difficile infections. Nat Rev Gastroenterol Hepatol 13:150–160. doi: 10.1038/nrgastro.2015.220. - DOI - PubMed
    1. Kelly CP, Kyne L. 2011. The host immune response to Clostridium difficile. J Med Microbiol 60:1070–1079. doi: 10.1099/jmm.0.030015-0. - DOI - PubMed
    1. Dubberke ER, Han Z, Bobo L, Hink T, Lawrence B, Copper S, Hoppe-Bauer J, Burnham CA, Dunne WM Jr. 2011. Impact of clinical symptoms on interpretation of diagnostic assays for Clostridium difficile infections. J Clin Microbiol 49:2887–2893. doi: 10.1128/JCM.00891-11. - DOI - PMC - PubMed

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