Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun;14(6):342-360.
doi: 10.1038/nrcardio.2017.23. Epub 2017 Mar 9.

Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology

Affiliations
Review

Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology

Camila Lopez-Crisosto et al. Nat Rev Cardiol. 2017 Jun.

Abstract

Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent on a sustained energy supply and adequate calcium buffering, both of which are provided by mitochondria. Moreover, in vascular smooth muscle cells, mitochondrial metabolism modulates cell growth and proliferation, whereas cytosolic calcium levels regulate the arterial vascular tone. Physical and functional communication between mitochondria and sarco/endoplasmic reticulum and balanced mitochondrial dynamics seem to have a critical role for optimal calcium transfer to mitochondria, which is crucial in calcium homeostasis and mitochondrial metabolism in both types of muscle cells. Moreover, mitochondrial dysfunction has been associated with myocardial damage and dysregulation of vascular smooth muscle proliferation. Therefore, sarco/endoplasmic reticulum-mitochondria coupling and mitochondrial dynamics are now viewed as relevant factors in the pathogenesis of cardiac and vascular diseases, including coronary artery disease, heart failure, and pulmonary arterial hypertension. In this Review, we summarize the evidence related to the role of sarco/endoplasmic reticulum-mitochondria communication in cardiac and vascular muscle physiology, with a focus on how perturbations contribute to the pathogenesis of cardiovascular disorders.

PubMed Disclaimer

References

    1. Mol Biol Cell. 2011 Apr 15;22(8):1263-73 - PubMed
    1. Sci Rep. 2014 Jun 05;4:5194 - PubMed
    1. Circ Res. 2012 May 25;110(11):1484-97 - PubMed
    1. Circ Res. 2015 Apr 10;116(8):1477-90 - PubMed
    1. J Cell Biol. 2009 Sep 21;186(6):805-16 - PubMed

Publication types

MeSH terms

LinkOut - more resources