Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun;10(2):173-177.

Paraoxonase 1 - an Update of the Antioxidant Properties of High- Density Lipoproteins

Bogdan Nicolae Manolescu  1 , Carmina Busu  2 , Daniela Badita  3 , Ruxandra Stanculescu  4 , Mihai Berteanu  5
Affiliations

Paraoxonase 1 - an Update of the Antioxidant Properties of High- Density Lipoproteins

Bogdan Nicolae Manolescu et al. Maedica (Bucur). 2015 Jun.

Abstract

Paraoxonase 1 (PON1) belongs to a family of enzymes with related functions, being the best studied member. PON1 is a HDL-associated protein of which function is to protect LDL particles from oxidative modifications. The status of PON1 is influenced by different genetic, life style and dietary factors. This short review is aimed to present some new aspects regarding the antioxidant properties of PON1 with emphasis on the influence exerted by different factors. Also, a special attention is paid to the relationship between PON1 and low- and high-density lipoproteins in the context of atherosclerosis which affects the endothelial cells.

PubMed Disclaimer

References

    1. Primo-Parmo SL, Sorenson RC, Teiber J, et al. - The human serum paraoxonase/ arylesterase gene (PON1) is one member of a multigene family. Genomics. 1996;33:498–507. - PubMed
    1. Martinelli N, Consoli L, Girelli D, et al. - Chapter 3: Paraoxonases: ancient substrate hunters and their evolving role in ischemic heart disease. Adv Clin Chem. 2013;59:65–100. - PubMed
    1. Elias M, Tawfik DS. – Divergence and convergence in enzyme evolution: parallel evolution of paraoxonases from quorum-quenching lactonases. J Biol Chem. 2012;287:11–20. - PMC - PubMed
    1. Camps J, Marsillach J, Joven J - The paraoxonases: role in human diseases and methodological difficulties in measurement. Crit Rev Clin Lab Sci. 2009;46:83–106. - PubMed
    1. Aragones G, Guardiola M, Barreda M, et al. - Measurement of serum PON-3 concentration: method evaluation, reference values, and the influence of genotypes in a population based study. J Lipid Res. 2011;52:1055–1061. - PMC - PubMed

LinkOut - more resources