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Comment
. 2017 Feb 16:4:11.
doi: 10.21037/sci.2017.02.03. eCollection 2017.

The bone marrow microenvironment-driver of leukemia evolution?

Mayra Garcia  1 , Ching-Cheng Chen  1
Affiliations
Comment

The bone marrow microenvironment-driver of leukemia evolution?

Mayra Garcia et al. Stem Cell Investig. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Mesenchymal stromal cells of the Sbds mouse model secrete pro-inflammatory signals S100A8/9 causing genotoxic stress to the HSPCs. The mesenchymal stromal cells are also deficient in their ability to differentiate into osteoblast although it is unclear if the pro-inflammatory signals play a role in this defect.
See this image and copyright information in PMC

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