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Case Reports
. 2017 Jan-Feb;20(1):58-62.
doi: 10.1177/1093526616671047.

Chronic Myelogenous Leukemia Presenting as a Secondary Malignancy After BCR-ABL1-negative B-lymphoblastic Leukemia/Lymphoma in a Pediatric Patient

Gheorghe Popa  1 , Cristina Blag  1 , Horatiu Olteanu  2
Affiliations
Case Reports

Chronic Myelogenous Leukemia Presenting as a Secondary Malignancy After BCR-ABL1-negative B-lymphoblastic Leukemia/Lymphoma in a Pediatric Patient

Gheorghe Popa et al. Pediatr Dev Pathol. 2017 Jan-Feb.

Abstract

Chronic myelogenous leukemia, BCR-ABL1 positive (CML) is a rare myeloproliferative neoplasm in children and presents even less often as a secondary malignancy in the pediatric population. Below, we report a patient with Philadelphia-negative B-lymphoblastic leukemia/lymphoma, who developed CML several years after achieving complete remission, and summarize the existing literature on the clinical and pathologic features of CML as a secondary pediatric malignancy.

Keywords: BCR-ABL1; chronic myelogenous leukemia; cytogenetics; flow cytometry; lymphoblastic leukemia/lymphoma.

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