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Case Reports
. 2017 Aug;17(8):2212-2214.
doi: 10.1111/ajt.14263. Epub 2017 Mar 30.

Improved Fetal Hemoglobin With mTOR Inhibitor-Based Immunosuppression in a Kidney Transplant Recipient With Sickle Cell Disease

N Gaudre  1 , P Cougoul  2 , P Bartolucci  3   4   5 , G Dörr  6   7 , A Bura-Riviere  1 , N Kamar  6   7   8 , A Del Bello  6
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Free article
Case Reports

Improved Fetal Hemoglobin With mTOR Inhibitor-Based Immunosuppression in a Kidney Transplant Recipient With Sickle Cell Disease

N Gaudre et al. Am J Transplant. 2017 Aug.
Free article

Abstract

Fetal hemoglobin induction is a key point in the management of sickle cell disease (SCD). We report the case of a kidney transplant recipient with SCD who was treated with everolimus, a mammalian target of rapamycin inhibitor. At 10 months after initiating therapy, the patient's fetal hemoglobin level was dramatically increased (from 4.8% to 15%) and there was excellent tolerance to treatment.

Keywords: anemia; clinical research/practice; everolimus; immunosuppressant; kidney disease; kidney transplantation/nephrology; mechanistic target of rapamycin.

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