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. 2017 May;28(7):616-628.
doi: 10.1080/09205063.2017.1289630. Epub 2017 Feb 23.

Biocompatible hyperbranched polyester magnetic nanocarrier for stimuli-responsive drug release

Chili Zhao  1 , Qiaorong Han  1 , Hong Qin  1 , Hong Yan  2 , Zhilei Qian  2 , Zhenye Ma  1 , Xia Zhang  2 , Xinghui Li  1
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Biocompatible hyperbranched polyester magnetic nanocarrier for stimuli-responsive drug release

Chili Zhao et al. J Biomater Sci Polym Ed. 2017 May.

Abstract

A novel biocompatible magnetic nanocomposite drug carrier was developed by first chemically modifying a hyperbranched polyester (HBPE) with dodecenyl succinic anhydride (DDSA) functional groups to produce HBPE-DDSA. The magnetic nanocomposite Fe3O4/HBPE-DDSA was then synthesized by dispersing superparamagnetic iron oxide (Fe3O4) nanoparticles within HBPE-DDSA. The structure and magnetic properties of the nanocomposite were characterized by 1H NMR, MALDI-MS, XRD, FTIR, TEM, and SQUID analyses. Isoniazid (INH) was selected as a model antituberculosis drug to investigate the in vitro drug release properties of Fe3O4/HBPE-DDSA/INH. The cytotoxicity of the magnetic nanocomposites was assessed by CCK-8 assay. The results indicated that Fe3O4/HBPE-DDSA is a promising potential drug carrier for a magnetic-targeted drug delivery system.

Keywords: Hyperbranched polyester; biocompatibility; magnetic nanocomposites; magnetic targeted drug delivery system (MTDs).

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