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. 2017 Feb;2(4):213-218.
doi: 10.1159/000452998. Epub 2016 Dec 14.

Evidence of AS3MTd2d3-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders

Lingyi Li  1 , Hong Chang  1 , Tao Peng  1 , Ming Li  1 , Xiao Xiao  1
Affiliations

Evidence of AS3MTd2d3-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders

Lingyi Li et al. Mol Neuropsychiatry. 2017 Feb.

Abstract

Genome-wide association studies suggest that 10q24.32-33 is a risk region for schizophrenia (SCZ). Considering the substantial genetic overlap between SCZ and major affective disorders, we would like to investigate whether the 10q24.32-33 region confers risk of affective disorders. We chose three SCZ genome-wide significant SNPs (rs7914558, rs7085104, and rs11191580) in 10q24.32-33 and collected the statistical data from European and Asian populations to perform systematic meta-analyses, which finally included up to 26,413 cases with affective disorders and 24,849 controls. Meta-analyses showed that all SNPs were nominally associated with major affective disorders. Considering the a priori evidence that these SNPs were associated with the expression of AS3MTd2d3 isoform in the human brain, our data confirms the potential involvement of AS3MTd2d3 in the genetic risk of major affective disorders.

Keywords: 10q24.32–33; AS3MTd2d3; Major affective disorders; Schizophrenia.

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Figures

Fig. 1
Fig. 1
Linkage disequilibrium relationship of the included SNPs in Europeans and Asians.
Fig. 2
Fig. 2
Literature search flow chart.
Fig. 3
Fig. 3
Forest plot of meta-analysis for the included SNPs with major affective disorders: rs7914558 (a), rs7085104 (b), and rs11191580 (c). The results for BPD samples are marked in dark gray, and results for MDD samples are marked in light gray.
See this image and copyright information in PMC

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