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. 2016 Winter;13(4):226-235.
doi: 10.1900/RDS.2016.13.226. Epub 2017 Feb 10.

Mediterranean Diet and 10-year (2002-2012) Incidence of Diabetes and Cardiovascular Disease in Participants with Prediabetes: The ATTICA study

Theodosios D Filippatos  1 , Demosthenes B Panagiotakos  1 , Ekavi N Georgousopoulou  1 , Evangelia Pitaraki  1 , Georgia-Maria Kouli  1 , Christina Chrysohoou  2 , Dimitrios Tousoulis  2 , Christodoulos Stefanadis  2 , Christos Pitsavos  2 ; ATTICA Study Group
Affiliations

Mediterranean Diet and 10-year (2002-2012) Incidence of Diabetes and Cardiovascular Disease in Participants with Prediabetes: The ATTICA study

Theodosios D Filippatos et al. Rev Diabet Stud. 2016 Winter.

Abstract

Background: Prediabetes has been related to an increased risk of developing diabetes and cardiovascular disease (CVD).

Aim: The aim of the present study was to examine the effect of the Mediterranean diet on diabetes and CVD risk in subjects with impaired fasting glucose (IFG, i.e. fasting plasma glucose 100-125 mg/dl).

Methods: During 2001-2002, 3042 men and women (>18y) were enrolled for the study. The participants showed no clinical evidence of CVD or any other chronic disease, and were living in the greater Athens (Greece) area. In 2011 and 2012, the 10-year follow-up examinations were performed, including a working sample of n = 1875 participants without diabetes at baseline. Adherence to the Mediterranean diet at baseline evaluation was assessed using the MedDietScore (range 0-55).

Results: The prediabetic subjects (n = 343) had a significantly higher incidence of diabetes (25% vs. 10%, p < 0.001) and CVD (17.8% vs. 12.3%, p = 0.007) compared with subjects with normal glucose values. A significant trend towards lower diabetes and CVD incidence was observed with medium and high adherence to the Mediterranean diet compared with low adherence (p < 0.001). High adherence to the Mediterranean diet (>35/55 score) was associated with lower 10-year incidence of diabetes and CVD. In multiple logistic regression models, participants with high levels of adherence to the Mediterranean diet were significantly less affected by diabetes and CVD than those with low adherence levels.

Conclusion: High adherence to the Mediterranean diet is associated with a low risk of developing diabetes and CVD in prediabetic subjects.

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Conflict of interest statement

The authors reported no conflict of interests.

References

    1. International Diabetes Federation. IDF diabetes atlas. Sixth edition 2013.
    1. Esposito K, Chiodini P, Maiorino MI, Bellastella G, Panagiotakos D, Giugliano D. Which diet for prevention of type 2 diabetes? A meta-analysis of prospective studies. Endocrine. 2014;47:107–116. - PubMed
    1. American Diabetes Association. Standards of medical care in diabetes 2014. Diabetes Care. 2014;37(Suppl 1):S14–S80. - PubMed
    1. Moutzouri E, Tsimihodimos V, Rizos E, Elisaf M. Prediabetes: to treat or not to treat? Eur J Pharmacol. 2011;672:9–19. - PubMed
    1. Esposito K, Maiorino MI, Bellastella G, Chiodini P, Panagiotakos D, Giugliano D. A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ Open. 2015;5(8):e008222. - PMC - PubMed

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