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. 2017 Aug;31(15):1733-1738.
doi: 10.1080/14786419.2017.1290615. Epub 2017 Feb 16.

New naphthalene derivative from the leaves of Cassia grandis L

Pham Thi Nhat Trinh  1 , Ngoc Quoc Luan  2 , Mai Dinh Tri  3 , Vu Duy Khanh  2 , Nguyen Huu An  4 , Phan Nhat Minh  3 , Pham Ngoc An  4 , Nguyen Thi Le Thuy  5 , Nguyen Kim Phi Phung  6 , Le Tien Dung  4
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New naphthalene derivative from the leaves of Cassia grandis L

Pham Thi Nhat Trinh et al. Nat Prod Res. 2017 Aug.

Abstract

Cassia grandis is used for the treatment of skin disorders, back pain, aches, etc. in Vietnamese traditional medicine. In this paper, phytochemicals of the leaves were investigated. A new naphthalene derivative (1, cassgranon D) and, seven known compounds rutin (2), afzelin (3), quercitrin (4), epicatechin (5), (-)-epiafzelechin (6), isoquercitrin (7) and aloe emodin (8) were isolated from the ethyl acetate and methanol extracts. Their structures were elucidated by spectral evidences (UV, IR, MS, 1H, 13C, DEPT, HSQC and HMBC NMR), as well as by comparing with published data.

Keywords: Cassgranon D; Cassia grandis; naphthalene derivative.

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