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. 2017 May 1:102:156-160.
doi: 10.1016/j.ejps.2017.03.005. Epub 2017 Mar 7.

Evaluation of CAAX prenyl protease II of Leishmania donovani as potential drug target: Infectivity and growth of the parasite is significantly lowered after the gene knockout

Ruchika Bhardwaj  1 , Mousumi Das  1 , Shalini Singh  1 , Adarsh Kumar Chiranjivi  1 , Sitraraau Vijaya Prabhu  2 , Sanjeev Kumar Singh  2 , Vikash Kumar Dubey  3
Affiliations

Evaluation of CAAX prenyl protease II of Leishmania donovani as potential drug target: Infectivity and growth of the parasite is significantly lowered after the gene knockout

Ruchika Bhardwaj et al. Eur J Pharm Sci. .

Abstract

Prenylation pathway is responsible for post translational modification of various signal proteins, including proteins of Ras superfamily. CAAX prenyl proteases are known to be key players in prenylation pathway. In the current study, we have evaluated CAAX prenyl protease II as a possible drug target against Leishmania donovani parasite, the causative agent of visceral leishmaniasis. Gene knockout strategy was employed to target CAAX prenyl protease II and subsequent effects were studied. CAAX prenyl protease II knockout resulted in significant decrease in growth and infectivity.

Keywords: CAAX prenyl protease II; Gene knockout; Leishmania; Ras protein; Target identification.

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