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. 1987 Nov;6(11):3379-84.
doi: 10.1002/j.1460-2075.1987.tb02660.x.

Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection

H Shida  1 , T Tochikura, T Sato, T Konno, K Hirayoshi, M Seki, Y Ito, M Hatanaka, Y Hinuma, M Sugimoto, et al.
Affiliations

Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection

H Shida et al. EMBO J. 1987 Nov.

Abstract

The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.

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