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Review
. 2017 Mar 1:11:547-552.
doi: 10.2147/DDDT.S110264. eCollection 2017.

Defective DNA repair mechanisms in prostate cancer: impact of olaparib

Francesca De Felice  1 , Vincenzo Tombolini  1 , Francesco Marampon  2 , Angela Musella  3 , Claudia Marchetti  3
Affiliations
Review

Defective DNA repair mechanisms in prostate cancer: impact of olaparib

Francesca De Felice et al. Drug Des Devel Ther. .

Abstract

The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) mutations are implicated in the highest risk of prostate cancer (PC) predisposition and aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP) proteins play a key role in DNA repair mechanisms and represent a valid target for new therapies. Olaparib is an oral PARP inhibitor that blocks DNA repair pathway and coupled with BRCA mutated-disease results in tumor cell death. In phase II clinical trials, including patients with advanced castration-resistant PC, olaparib seems to be efficacious and well tolerated. Waiting for randomized phase III trials, olaparib should be considered as a promising treatment option for PC.

Keywords: BRCA; DNA-repair; PARP; castration resistant; metastatic disease; olaparib; prostate cancer.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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References

    1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. - PubMed
    1. Pritchard CC, Mateo J, Walsh MF, et al. Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N Engl J Med. 2016;375(5):443–453. - PMC - PubMed
    1. Eeles RA. Genetic predisposition to prostate cancer. Prostate Cancer Prostatic Dis. 1999;2(1):9–15. - PubMed
    1. Leongamornlert D, Saunders E, Dadaev T, et al. Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease. Br J Cancer. 2014;110(6):1663–1672. - PMC - PubMed
    1. Castro E, Goh C, Olmos D, et al. Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. J Clin Oncol. 2013;31(14):1748–1757. - PMC - PubMed

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