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Review
. 2017 Feb 23:8:74.
doi: 10.3389/fphar.2017.00074. eCollection 2017.

Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review

Weiwei Li  1 , Guoqi Yuan  1 , Yuxiang Pan  1 , Cong Wang  1 , Haixia Chen  1
Affiliations
Review

Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review

Weiwei Li et al. Front Pharmacol. .

Abstract

Diabetes mellitus (DM) is a kind of chronic and metabolic disease, which can cause a number of diseases and severe complications. Network pharmacology approach is introduced to study DM, which can combine the drugs, target proteins and disease and form drug-target-disease networks. Network pharmacology has been widely used in the studies of the bioactive compounds and action mechanisms of natural products for the treatment of DM due to the multi-components, multi-targets, and lower side effects. This review provides a balanced and comprehensive summary on network pharmacology from current studies, highlighting different bioactive constituents, related databases and applications in the investigations on the treatment of DM especially type 2. The mechanisms related to type 2 DM, including α-amylase and α-glucosidase inhibitory, targeting β cell dysfunction, AMPK signal pathway and PI3K/Akt signal pathway are summarized and critiqued. It suggests that the network pharmacology approach cannot only provide a new research paradigm for natural products, but also improve the current antidiabetic drug discovery strategies. Furthermore, we put forward the perspectives on the reasonable applications of network pharmacology for the therapy of DM and related drug discovery.

Keywords: database; diabetes mellitus; mechanism; natural products; network pharmacology.

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Figures

FIGURE 1
FIGURE 1
Summary of signal pathways related to diabetes mellitus. Pathway diagram keys: formula image Direct stimulatory modification; formula image Direct inhibitory modification; formula image Translocation; formula image Multistep stimulatory modification.
See this image and copyright information in PMC

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