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. 1988 Feb;99(2):454-60.
doi: 10.1016/0014-4886(88)90162-8.

Effect of ACTH4-10 on nerve fiber regeneration after sciatic nerve crush in rabbits: an electrophysiological and morphological study

P Girlanda  1 , U Muglia, G Vita, R Dattola, M Santoro, A Toscano, C Venuto, M L Roberto, A Baradello, M Romano, et al.
Affiliations

Effect of ACTH4-10 on nerve fiber regeneration after sciatic nerve crush in rabbits: an electrophysiological and morphological study

P Girlanda et al. Exp Neurol. 1988 Feb.

Abstract

Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fibers were measured in semithin nerve sections at 1 and 3 cm distal from the crushed point at three different time points. Nerve fiber density results were higher in ACTH4-10-than in vehicle-treated rabbits. This difference showed an unequivocal trend and attained a statistically significant level in the sections 3 cm distal from the crush. ACTH4-10 seemed therefore to have a beneficial effect on nerve fiber regeneration.

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