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Review
. 2017 Mar 1;31(2):93-95.
doi: 10.2500/ajra.2017.31.4412. Epub 2017 Mar 9.

Monoclonal antibody therapy in sinonasal disease

Sergio E Chiarella  1 , Hendrik Sy, Anju T Peters
Affiliations
Review

Monoclonal antibody therapy in sinonasal disease

Sergio E Chiarella et al. Am J Rhinol Allergy. .

Abstract

Chronic rhinosinusitis (CRS) affects 12.5% of the U.S.

Population: CRS can be divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps. Some individuals with CRSwNP do not respond to standard-of-care medical and surgical management. For these individuals, targeted biologic agents are emerging as an important therapeutic alternative. In this review, we described the most-relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-interleukin 5 (mepolizumab and reslizumab), and anti-interleukin 4/interleukin 13 (dupilumab) monoclonal antibodies for the treatment of CRSwNP. In addition, we discussed the importance of some of these clinical trials in identifying new CRS endotypes based on distinct inflammatory profiles.

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