doi: 10.1101/gad.1.9.931.
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae
- PMID: 2828175
- DOI: 10.1101/gad.1.9.931
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Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae
Genes Dev.
1987 Nov.
Free article
Erratum in
- Genes Dev 1987 Dec;1(10):1351
Abstract
We have isolated and characterized normal and mutant alleles of many of the genes of the RAS/adenylyl cyclase pathway of the yeast Saccharomyces cerevisiae. Manipulation of those genes has revealed a system for feedback control that can modulate cAMP levels over at least a 10,000-fold range. The feedback control depends upon the activity of the cAMP-dependent protein kinases and requires the presence of the CDC25 and RAS proteins. The capacity for such dramatic control of cAMP levels raises fundamental questions about the normal mechanism of action of the cAMP signaling system in yeast.
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